3. Molecular Assembly of Peptide

Self-assembly of peptide molecules have aroused great concerns owing to their structural simplicity, biocompatibility, chemical versatility, facile synthesis, and widespread applications. One well-known and the simplest peptide building block is diphenylalanine (FF), the core recognition motif of the Alzheimer's β-amyloid polypeptide. Our group have done substantial researches on the self-assembly of FF and their applications in biomedicine. The polymorphism of FF-based assembly were obtained and easily controlled by the experimental conditions such as solvents, peptide concentrations and crosslinking agents. We hope our approach could help to enrich the diversity of FF-based peptides' assemblies and shed light on the preparation of bio-functional materials. Adv. Funct. Mater. 2015, 25, 1193; Small 2015, 11, 1787; Chem. Eur. J. 2015, 21, 9461; Adv. Opt. Mater. 2015, 3, 194; Chem. Commun. 2015, 51, 7219; ACS Nano 2015, 9, 2689; Angew. Chem. Int. Ed. 2014, 53, 2366; Chem. Commun. 2013, 49, 9956; ACS Nano 2012, 6, 111; Angew. Chem. Int. Ed. 2011, 50, 11186; Adv. Mater. 2011, 23, 2796; Chem. Soc. Rev. 2010, 39, 1877; Adv. Mater. 2010, 22, 1283.

Various Nanostructures Formed by Self-assembly of FF-based Building Blocks

The Transition Between Peptide Nanotubes and Vesicle-like Structures, and Its Theoretical Model

Uniaxially Oriented Peptide Crystals for Active Optical Waveguiding

One-Pot Synthesis of Polypeptide-Gold Nanoconjugates for in Vitro Gene Transfection

Self-assembly and Application of Diphenylalanine-based Nanostructures